Science Immunology[IF:30.63]

① 肠道菌群衍生代谢物TMAO可增强对PDAC的抗肿瘤免疫；② 腹腔内或补充膳食胆碱以向PDAC模型小鼠递送TMAO，或静脉输注经TMAO刺激的巨噬细胞，能减少肿瘤生长；③ TMAO增强I型干扰素途径，诱导免疫刺激性肿瘤相关巨噬细胞表型、激活肿瘤微环境的效应T细胞；④ TMAO联合免疫检查点阻断疗法能显著降低PDAC小鼠的肿瘤负荷，改善生存率；⑤ 含CutC（产生TMAO前体的酶）的细菌水平与PDAC患者的长期生存和黑色素瘤患者对anti-PD1反应改善相关。

The microbiome-derived metabolite TMAO drives immune activation and boosts responses to immune checkpoint blockade in pancreatic cancer
09-09, doi: 10.1126/sciimmunol.abn0704